Hydroxamic Acid Derivatives as Potent Peptide Deformylase Inhibitors and Antibacterial Agents

Low-molecular-weight <i>β</i>-sulfonyl- and <i>β</i>-sulfinylhydroxamic acid derivatives have been synthesized and found to be potent inhibitors of <i>Escherichia coli</i> peptide deformylase (PDF). Most of the compounds synthesized and tested displayed antibacterial activities that cover several pathogens found in respiratory tract infections, including <i>Chlamydia pneumoniae, Mycoplasma pneumoniae, Haemophilus </i><i>influenzae,</i> and <i>Moraxella catarrhalis</i>. The potential of these compounds as antibacterial agents is discussed with respect to selectivity, intracellular concentrations in bacteria, and potential for resistance development.