Histological analysis of the lungs from bleomycin-treated mice in the presence or absence of Compound A or pirfenidone treatment.

Representative histology from Masson’s Trichrome stained sections of saline-instilled mice, vehicle treated, Compound A treated and pirfenidone treated mice are shown in panel (G). MAP3K19 staining of bleomycin treated mouse lungs, from a separate experiment, is shown in the Supplementary Data (S4 Fig).