lsyc_a_1428346_sm8211.doc (3.26 MB)
Highly efficient Brønsted acid and Lewis acid catalysis systems for the Friedländer Quinoline synthesis
journal contribution
posted on 2018-03-19, 18:11 authored by Xiao-Yu Zhou, Xia Chen, Liang-Guang WangThe efficient and green Brønsted acid or Lewis acid catalysis systems for the Friedländer synthesis of 2,3,4-trisubstituted quinolines from the condensation of 2-aminoarylketones and β-ketoesters/ketones had been developed. The results confirmed that 4-toluenesulfonic acid, magnesium chloride, and cupric nitrate were the desired catalyst independently. This protocol had the advantages of mild conditions, operational simplicity, and excellent yields.