Highly Enantioselective Quinoline Synthesis via Ene-type Cyclization of 1,7-Enynes Catalyzed by a Cationic BINAP−Palladium(II) Complex

The first highly enantioselective synthesis of a six-membered ring quinoline catalyzed by a cationic BINAP−palladium(II) complex is shown to afford the quinoline products having a quaternary carbon center or a spiro-ring in quantitative yield and >99% ee.