Highly Enantioselective Hydrogenation of <i>ο</i>‑Alkoxy Tetrasubstituted Enamides Catalyzed by a Rh/(<i>R</i>,<i>S</i>)‑JosiPhos Catalyst

Rh/(<i>R,S</i>)-JosiPhos complex-catalyzed asymmetric hydrogenation of <i>o</i>-alkoxy tetrasubstituted enamides has been achieved, and it furnished a set of β-amino alcohol analogues in high yields and excellent enantiomeric excesses (>99% conversion, up to 99% ee).This method provides valuable chiral building blocks in chiral pharmaceuticals and useful motifs for catalysts.