ol5b00401_si_001.pdf (2.99 MB)
Highly Enantioselective Hydrogenation of ο‑Alkoxy Tetrasubstituted Enamides Catalyzed by a Rh/(R,S)‑JosiPhos Catalyst
journal contribution
posted on 2015-04-17, 00:00 authored by Jingjing Meng, Min Gao, Hui Lv, Xumu ZhangRh/(R,S)-JosiPhos complex-catalyzed asymmetric hydrogenation
of o-alkoxy tetrasubstituted enamides has been achieved,
and it furnished a set of β-amino alcohol analogues in high
yields and excellent enantiomeric excesses (>99% conversion, up
to 99% ee).This method provides valuable chiral building blocks in
chiral pharmaceuticals and useful motifs for catalysts.