High-Throughput Toxicokinetics Data

It is important to link the external dose of a chemical to an internal blood or tissue concentration; this process is called toxicokinetics. EPA researchers measure the critical factors that determine the distribution and metabolic clearance for hundreds of chemicals and incorporate these data into computer models. The high-throughput toxicokinetic data can be paired with the high-throughput screening data to estimate real-world exposures. �