Heterogeneity in Adrenal Cortical Proliferative Lesions – Cellular and Molecular Bases

Heterogeneity is inherent to adrenal cortical morphology and function
Heterogeneity is a defining feature of neoplastic progression
Neoplastic heterogeneity results in cellular segregation and it is associated with clonal evolution, mitogenic status and vascular network.
Gene profiling need to be evaluated on the light of this key feature