Heatmap and enrichment of chromatin states around transcription start sites (TSS) of five developmental stages of the Schistosoma mansoni life cycle.

(A) Heatmap of miracidia stage for H3K4me3, H3K27me3 and H3K4me3+H3K27me3. (B) Heatmap of sporocyst stage for H3K4me3, H3K27me3 and H3K4me3+H3K27me3. (C) Heatmap of cercaria stage for H3K4me3, H3K27me3 and H3K4me3+H3K27me3. (D) Heatmap of miracidia stage for H3K4me3, H3K27me3 and H3K4me3+H3K27me3. (E) Heatmap of miracidia stage for H3K4me3, H3K27me3 and H3K4me3+H3K27me3. Logarithms (observed/ expected) for each histone modification were plotted along S. mansoni genome and 4 kb upstream and downstream for each stage (A-E). Colors: Blue = H3k4me3; Yellow = H3K27me3; Purple = H3K4me3+H3K27me3.