HIV Env trimer N-glycans and the CD4bs.

Structure of soluble BG505 SOSIP.664 HIV trimer (PDB accession number 5FYL) with gp120 in gray, gp41 in brown and the CD4bs shown as a magenta surface. N-glycans are shown in shades of blue. (a) The Group A N-glycans proximal to the CD4bs are shown in dark blue as indicated in bold and the N332 N-glycan is shown in dark turquoise. (b) The Group B N-glycans proximal to the CD4bs are shown in dark blue and are indicated in bold. N332 N-glycan is shown in dark turquoise. (c) Trimer docking models of VRC01 (purple), b12 (red) and CH103 (yellow) Fabs, each approaching the CD4bs with different angles of access.