HD initiation and death-associated albumin dynamics estimated using generalized additive mixed models.

Upper panels: All the albumin measurements for the post-HD initiation subcohort or the before death subcohort were fitted using a generalized mixed model with the time interval as a fixed variable and the subject ID as a random variable. The dotted lines represent the 95% confidence interval of the fixed term. Lower panels: The moving CV values were calculated using all the albumin measurements that had been recorded in January 2007 or thereafter; these values were fitted using a generalized mixed model in a similar manner. Note that the moving CV values were not log-transformed. The number of analyzed subjects is labeled in each panel.