Gukulenins A and B, Cytotoxic Tetraterpenoids from the Marine Sponge Phorbas gukulensis

Park, Su Young; Choi, Hyukjae; Hwang, Hoosang; Kang, Heonjoong; Rho, Jung-Rae

doi:10.1021/np900606h.s001

np900606h_si_001.pdf (859.53 kB)

Gukulenins A and B, Cytotoxic Tetraterpenoids from the Marine Sponge Phorbas gukulensis

journal contribution

posted on 2010-04-23, 00:00 authored by Su Young Park, Hyukjae Choi, Hoosang Hwang, Heonjoong Kang, Jung-Rae Rho

Gukulenins A (1) and B (2), both having an unprecedented skeleton with a bis-tropolone moiety, were isolated from the Korean marine sponge Phorbas gukulensis. They exhibited significant cytotoxicity against human pharynx, stomach, colon, and renal cancer cell lines in the range 0.05−0.80 μM.