ao7b01279_si_002.cif (212.67 kB)
Green Method To Preparing Oxindole-Fused Spirotetrahydrofuran Scaffolds through Methanesulfonic Acid-Catalyzed Cyclization Reactions of 3‑Allyl-3-hydroxy-2-oxindole in Water
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posted on 2017-10-20, 15:52 authored by Jie-Huan Zhang, Ru-Bing Wang, De-Feng Li, Li-Ming ZhaoWater is an ideal solvent for chemical transformations in environmentally
friendly and sustainable processes. An operationally simple, metal-free,
and green approach to the synthesis of oxindole-fused spirotetrahydrofurans
from 3-allyl-3-hydroxy-2-oxindoles in water is described. This method
requires only cheap methanesulfonic acid as a catalyst and eliminates
the need of complicated reagents. This atom- and step-economical transformation
is highly efficient, which provides a new approach for the construction
of oxindole-fused spirotetrahydrofuran molecules with potential pharmaceutical
interest.
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methanesulfonic acidPreparing Oxindole-Fused Spirotetrahydrofuran Scaffoldschemical transformationsstep-economical transformationoxindole-fused spirotetrahydrofuransAllylmethodapproachoxindole-fused spirotetrahydrofuran moleculesreagentmetal-freeconstructionMethanesulfonic Acid-Catalyzed Cyclization Reactions3- allyl -3-hydroxyWater WaterGreen Methodsynthesiscatalyst
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