Green Approach Toward One Pot Cascade Synthesis of 3-Aryl-3,4-Dihydro-1,2,4 Benzothiadiazine-1,1-Dioxides

<div><p></p><p>A silica-gel-supported ceric ammonium nitrate (CAN-SiO<sub>2</sub>) was found to be an effective catalyst for the cascade synthesis of functionalized 3-aryl-3,4-dihydro-1,2,4-benzo- thiadiazine-1,1-dioxides using 2-aminobenzenesulfonamide and benzaldehydes at room temperature. The reaction allows rapid cyclization (10−70 min) with 5 mol% CAN impregnated on silica gel to give the desired products in excellent yield without further column purification. The protocol uses inexpensive and environmentally friendly CAN-SiO<sub>2</sub>as the catalyst, and no ligand or additive was required.</p> <p> <i>[Supplementary materials are available for this article. Go to the publisher's online edition of</i><i>Phosphorus, Sulfur, and Silicon and the Related Elements</i> for the following free supplemental files: Additional figures]</p> </div>




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