Glycosidic exclusion and phenotype formation.pdf (215.46 kB)
Glycosidic exclusion and phenotype formation
ABO (H)
phenotype and innate isoagglutinin specificities as they arise from “glycosidic
exclusion”. Scheme demonstrating how fucosylation provides ABO(H) “blood group
completeness”: The germline-encoded, polyreactive ancestral IgM emerges as a
glycan-depleted molecule from non-somatic germ cell maturation and
developmental cell renewal or growth processes. Although the specific timing
between the encodings of the fucosyl-, GalNAc-, and D-Gal transferases remains
an open question, fucosylation occurs on both the cell surface and plasma
proteins, followed by the transfer of GalNAc and D-Gal to the cell surfaces and
the complementary domains of the differentiating IgM. The glycosidic formation
of phenotypes and circulating IgM specificities occurs in identical enzymatic
steps. Figure reconstructed from Arend, P. ABO (histo) blood group
phenotype development and human reproduction
as they relate to ancestral IgM formation: A hypothesis. Immunobiology
221, 116–127 (2016).