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Genome browser view of the raw PRO-seq signal near the SOX9 gene in d39 gonads.

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posted on 2017-10-20, 20:05 authored by Vicki N. Meyers-Wallen, Adam R. Boyko, Charles G. Danko, Jennifer K. Grenier, Jason G. Mezey, Jessica J. Hayward, Laura M. Shannon, Chuan Gao, Afrah Shafquat, Edward J. Rice, Shashikant Pujar, Stefanie Eggers, Thomas Ohnesorg, Andrew H. Sinclair

SOX9 expression was not significantly elevated in d39 XX DSD gonads at risk compared to those of XX age-matched controls. The SOX9 signal is highest in XY littermate control gonads (C3640, C3639, C3557) and much lower in the age-matched XX control (A1114) and XX DSD gonads at risk (C3641, C3682, C3556, C3681). For each sample, histograms show reads aligned to the plus strand (top, red) and minus strand (bottom, blue). Listed at left are embryo ID number, group (XX/XY) and genotype at the insertion locus: wild type (-/-), homozygous (G+G+), and heterozygous (G+/-) for the guanine insertion associated with XX DSD. RefSeq gene annotation is shown below the plot (CanFam3.1).

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