ic6b01159_si_001.pdf (2.35 MB)
Gallium and Functionalized-Porphyrins Combine to Form Potential Lysosome-Specific Multimodal Bioprobes
journal contribution
posted on 2016-06-29, 17:21 authored by Jie Pan, Bethany I. Harriss, Chi-Fai Chan, Lijun Jiang, Tik-Hung Tsoi, Nicholas J. Long, Wing-Tak Wong, Wai-Kwok Wong, Ka-Leung WongA water-soluble bimetallic
normal (“cold”) and radiochemical (“hot”)
gallium–porphyrin–ruthenium–bipyridine complex
(GaporRu-1) has been synthesized by microwave methodology
in short reaction times with
good (>85%) yields. 68GaporRu-1 is demonstrated to be a potential multimodal and functional bioprobe
for positron emission tomography (PET), lysosome specific optical
imaging, and photodynamic therapy.