Gabapentin for Neuropathic Pain: An application to the 21st meeting of the WHO Expert Committee on Selection and Use of Essential Medicines for the inclusion of gabapentin on the WHO Model List of Essential Medicines

<h2>ABOUT</h2><p>This repository contains all the files required to generate the application (and supporting documents) the International Association for the Study of Pain (IASP) and the International Association of Hospice and Palliative Care (IAHPC) made to the 21st meeting of the WHO Expert Committee on Selection and Use of Essential Medicines (2017) for the inclusion of gabapentin on the WHO Model List of Essential Medicines for the treatment of neuropathic pain.</p><p>For a brief summary of why we have applied for the inclusion of an additional medicine to treat neuropathic pain on the WHO Model List, see:</p><ul><li><a href="http://painblogr.org/neuropathic-pain-storyboard-2016/">Neuropathic pain: so many people, but where are the drugs?</a></li><li>World Health Organization essential medicines lists: where are the drugs to treat neuropathic pain? <em>PAIN</em>156:793-797, 2015. DOI: <a href="http://dx.doi.org/10.1097/01.j.pain.0000460356.94374.a1">10.1097/01.j.pain.0000460356.94374.a1</a>, PMC: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670621/pdf/nihms701453.pdf">4670621</a></li></ul><h2><a href="https://github.com/kamermanpr/WHO-EML-application-2016#citation"></a>CITATION</h2><p>Kamerman PR, Finnerup NB, De Lima L, Haroutounian S, Raja SN, Rice ASC, Smith BH, Treede RD. Gabapentin for neuropathic pain: An application to the 21st meeting of the WHO Expert Committee on Selection and Use of Essential Medicines for the inclusion of gabapentin on the WHO Model List of Essential Medicines. DOI: <a href="http://dx.doi.org/10.6084/m9.figshare.3814206.v2">10.6084/m9.figshare.3814206.v2</a>, 2016</p><h2><a href="https://github.com/kamermanpr/WHO-EML-application-2016#acknowledgements"></a>ACKNOWLEGEMENTS</h2><p>We are indebted to our four external reviewers for their constructive comments:</p><ul><li>Michael I Bennett (UK)</li><li>Daniel Ciampi de Andrada (Brazil)</li><li>G Allen Finley (Canada)</li><li>Telesphore B Nguelefack (Cameroon)</li></ul><p>We also thank Dr Nicola Magrini (Secretary of the Expert Committee on the Selection and Use of Essential Medicines) and Dr Tarun Dua (Department of Mental Health and Substance Abuse) for their assistance and constructive feedback.</p><h2><a href="https://github.com/kamermanpr/WHO-EML-application-2016#instructions"></a>INSTRUCTIONS</h2><h3><a href="https://github.com/kamermanpr/WHO-EML-application-2016#download-a-complete-copy"></a>Download a complete copy</h3><p>Click on this <a href="https://dl.dropboxusercontent.com/u/11805474/painblogr/neuropathic-pain-storyboard-2016/eml-application.pdf">link</a> to access a PDF of the complete document (application and appendices).</p><h3><a href="https://github.com/kamermanpr/WHO-EML-application-2016#build-the-document"></a>Build the document</h3><p>Follow the steps below to compile the application, appendices, and the executive summary.</p><p>Windows users must first download and install:</p><ul><li><p><a href="https://github.com/git-for-windows/git/releases"><em>Git for Windows</em></a> or any other <em>Bash</em>-like shell for Windows.</p></li><li><p><a href="http://gnuwin32.sourceforge.net/downlinks/make.php"><em>GNU Make</em></a>.</p></li></ul><h4><a href="https://github.com/kamermanpr/WHO-EML-application-2016#if-you-use-gitgithub"></a>If you use Git/GitHub:</h4><ol><li><p><em>Fork</em> the repository to your GitHub account.</p></li><li><p><em>Clone</em> the repository to your computer.</p></li><li><p>Open a <em>terminal</em> and change the path to the directory of the respository.</p></li><li><p>Type <em>'make'</em>.</p></li></ol><h4><a href="https://github.com/kamermanpr/WHO-EML-application-2016#if-you-do-not-use-gitgithub"></a>If you do not use Git/GitHub:</h4><ol><li><p><em>Download</em> the repository as a zip file.</p></li><li><p><em>Unzip</em> the repository on your computer.</p></li><li><p>Open a <em>terminal</em> and change the path to the directory you unzipped the repository into.</p></li><li><p>Type <em>'make'</em>.</p></li></ol><h2><a href="https://github.com/kamermanpr/WHO-EML-application-2016#the-following-set-up-was-used-to-generate-all-files"></a>The following set-up was used to generate all files</h2><ul><li>R version 3.3.1 (2016-06-21) running on RStudio v1.0.44 for macOS Sierra</li><li>Packages used (inclusive of: <em>application.Rmd</em>, <em>appendices.Rmd</em>, <em>summary.Rmd</em>, and all other analysis scripts):</li><ul><li>cowplot 0.7.0</li><li>dplyr 0.5.0</li><li>ggplot2 2.2.0</li><li>gridExtra 2.2.1</li><li>knitr 1.15</li><li>pander 0.6.0</li><li>readr 1.0.0</li><li>rmeta 2.16</li><li>scales 0.4.1</li><li>stringr 1.1.0</li><li>tidyr 0.6.0</li><li>xtable 1.8-2</li></ul></ul><div><h2>LICENSE</h2><p>Gabapentin for neuropathic pain: An application to the 21st meeting of the WHO Expert Committee on Selection and Use of Essential Medicines for the inclusion of gabapentin on the WHO Model List of Essential Medicines by the <a href="http://www.iasp-pain.org/">International Association for the Study of Pain (IASP)</a> and the <a href="http://hospicecare.com/home/">International Association of Hospice and Palliative Care (IAHPC)</a> is licensed under a <a href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International License</a>.</p></div>