Method: 1. Region of interest based analysis (ROI-to-ROI) 2. Graph theoretical analysis
Data : The Center for Biomedical Research Excellence data set data set is used in this research which contains raw anatomical and functional MR data from 72 patients with Schizophrenia and 75 healthy controls, ranging in age from 18 to 65 years old. Resting fMRI, anatomical MRI, phenotype data for every participant including: gender, age, handedness and diagnostic information are released.
Tools: A Matlab-based cross-platform software functional connectivity toolbox (CONN) and SPM toolboxes are used for spatially preprocessing (Realignment, coregistering, normalization, ...) of structural and functional data.
Figures, tables and videos: CTR_SCH_3D.jpg Healthy control subjects connectivity vs. Schizophrenia patients (3D view). ROI-to-ROI connections intensities are threshold and FDR p- values= 0.01. Seed ROIs are thresholded and FDR p- values= 0.01. CTR_SCH.jpg Healthy control subjects connectivity vs. Schizophrenia patients (ROIs showed in ring only). CTR_SCH.txt Healthy control subjects connectivity vs. Schizophrenia patients (table). Graph_theory_measures_for_all_healthy_subjects_all_patients.jpg Graph-theory measures for all healthy subjects vs. all patients
Spatial_Components.jpg Spatial components with 10 factors and threshold=2
Estimated_dynamic_connectivity_CTL.avi Estimated dynamic connectivity of healthy control subjects Estimated_dynamic_connectivity_SCH.avi Estimated dynamic connectivity of Schizophrenia patients