Four new monacolin analogs from <i>Monascus purpureus</i>-fermented rice

<p>Four new monacolin analogs, monacolin T (<b>1</b>), monacolin U (<b>2</b>) 6<i>a</i>-<i>O</i>-methyl-4,6-dihydromonacolin L (<b>3</b>), and 6<i>a</i>-<i>O</i>-ethyl-4,6-dihydromonacolin L (<b>4</b>) were isolated from the ethanolic extract of <i>Monascus purpureus</i>-fermented rice. Their structures were determined by a combination of 1D, 2D NMR experiments (<sup>1</sup>H-<sup>1</sup>HCOSY, HSQC, HMBC, and ROESY), and mass spectrometry. <i>In vitro</i> cytotoxic assay, all compounds were inactive at the concentration of 10 µM.</p>