ol6b00311_si_001.pdf (2.87 MB)
Fluorescent Sensing of Guanine and Guanosine Monophosphate with Conjugated Receptors Incorporating Aniline and Naphthyridine Moieties
journal contribution
posted on 2016-03-28, 00:00 authored by Shao-Hung Lu, Riping Phang, Jim-Min FangEthyne-linked
naphthyridine–aniline conjugated molecules are selective sensors
of decylguanine in dichloromethane and guanosine monophosphate in
water (Kass = 16 000 M–1). The 2-acetamido-1,8-naphthyridine moiety binds with guanine in
a DAA–ADD triply hydrogen-bonded motif. The aniline moiety
enhances an electron-donating effect, and the substituent is tuned
to attain extra hydrogen bonds, π–π stacking, and
electrostatic interactions. The proposed binding modes are supported
by a Job plot, ESI-MS, 1H NMR, UV–vis, and fluorescence
spectral analyses.
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hydrogen bondsanalysesK asstriplyGuanineaniline moiety16 000DAAacetamidodecylguanineGuanosine Monophosphateguaninebinding modesFluorescentsensor1 H NMRJob plotdichloromethanemoleculesubstituentnaphthyridineMoietiefluorescenceNaphthyridinemotifUVConjugated Receptors Incorporating Anilineguanosine monophosphateinteraction
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