om9b00378_si_001.pdf (2.01 MB)
Fluorene Complexes of Group 9 Metals: Fluorene Effect and Application for Reductive Amination
journal contribution
posted on 2019-08-07, 17:34 authored by Vladimir
B. Kharitonov, Evgeniya Podyacheva, Yulia V. Nelyubina, Dmitry V. Muratov, Alexander S. Peregudov, Gleb Denisov, Denis Chusov, Dmitry A. LoginovThe
η6-fluorene cyclopentadienyl complexes [(η5-C5R5)M(η6-fluorene)](SbF6)2 (1: M = Co, R = Me; 2a: M = Rh, R = H; 2b: M = Ir, R = H) were synthesized
by the iodide abstraction from [(η5-C5R5)MI2]n with AgSbF6 in the presence of fluorene. The procedure is also suitable
for the synthesis of the indenyl derivatives [(η5-indenyl)M(η6-fluorene)](SbF6)2 (3a: M = Rh; 3b: M = Ir) starting from
[(η5-indenyl)MI2]n. The structures of [1](SbF6)2 and [2b](SbF6)2 were determined
by X-ray diffraction. The rhodium complex [2a](SbF6)2 readily undergoes the replacement of the fluorene
ligand by mesitylene, being more reactive than the benzene derivative
[CpRh(η6-C6H6)](SbF6)2. According to experimental data and DFT calculations,
the fluorene elimination proceeds via a cascade of η6 → η5 → η1 haptotropic
rearrangements. The complex [2b](SbF6)2 (at 1 mol % loading) effectively catalyzes the reductive
amination reaction between aldehydes (or ketones) and primary aromatic
(or secondary aliphatic) amines in the presence of carbon monoxide,
giving the corresponding secondary and tertiary amines in the range
of yields 59–91%. This protocol uses water as a solvent.