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Figure 3: Cardiac Metabolic Rates, Energy Production, and Cardiac Efficiency in

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posted on 2019-06-12, 08:29 authored by Subodh Verma, Sonia Rawat, Kim L. Ho, Cory S. Wagg, Liyan Zhang, Hwee Teoh, John E. Dyck, Golam M. Uddin, Gavin Y. Oudit, Eric Mayoux, Michael Lehrke, Nikolaus Marx, Gary D. Lopaschuk
Working heart perfusion derived palmitate (fatty acid) oxidation (n = 7 for db/db, n = 6 for db/db + 600 μM βOHB) (A), glucose oxidation (n = 5 for db/db, n = 8 for db/db + 600 μM βOHB) (B), and glycolysis (n = 4 to 5 for db/db, n = 7 to 8 for db/db + 600 μM βOHB) (C) levels. βOHB (ketone body) oxidation levels (n = 8 for db/db + 600 μM βOHB) (D) are also shown. Cardiac ATP production and comparison between contribution from glycolysis and the oxidation of glucose, palmitate, and βOHB (n = 5 to 8 for all groups) (E). Cardiac efficiency of the ex vivo heart as determined by normalizing cardiac work to oxygen consumption (n = 10 for db/db, n = 15 for db/db + 600 μM βOHB) (F). Data are presented as mean ± SEM. Data were analyzed by 1-way ANOVA followed by LSD post hoc test. Three separate 1-way ANOVAs were performed to determine each substrate’s contribution to ATP production. *p < 0.05 was considered as a significantly different comparison to the insulin-absent levels of the same group. For E, ‡p < 0.05 was considered as significantly different in comparison with the same group in the absence of insulin. Abbreviations as in Figures 1 and 2.

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    Journal of the American College of Cardiology

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