Human SOD1 overexpressed in motoneurons confers resistance to BMAA treatment.
2012-11-29T11:39:29Z (GMT) by
<p>Shown are survival rates of 5 day-old male <em>sod1</em> transgenic flies under 3 mM BMAA treatment (10 flies per vial). Panels A, B, and C represent the survival rate of flies expressing mutant human A4V, G85R, wild type SOD1 proteins and control flies (D42>CS and D42>UAS-<em>dsod1</em>) in motoneurons using the D42-Gal4 driver. Flies expressing the human SOD1s (both the hSOD1WT, and mutants, hSOD1A4V and hSOD1G85R) survived longer compared to the control flies. At the 50% survival rate, the longevity is increased by 33%, 41% and 66 % for A4V, G85R, wt SOD1, respectively, when compared to D42><em>dsod1</em> and D42>CS flies. Differences were considered statistically significant if pCS and D42>A4V, respectively; n=50 for the rest of genotypes.</p>