Figure 2: Protocols

Protocol 1 assesses the therapeutic effects of 5-week chronic vagal nerve stimulation (VNS) delivered by an implantable neurostimulator in free-moving rats with pulmonary arterial hypertension (PAH). Protocol 2 assesses the effects of 90-min acute VNS delivered by an external stimulation device in anesthetized rats with advanced PAH. CTRL = control; O2 = oxygen; SS = sham stimulation.