Fast and efficient green synthesis of thiosulfonate <i>S</i>-esters by microwave-supported permanganate oxidation of symmetrical disulfides

<div><p>Potassium permanganate absorbed on copper(II) sulfate pentahydrate has been found to be an efficient, inexpensive, and green oxidation agent for the synthesis of “symmetrical” thiosulfonate <i>S</i>-esters by oxidation of the corresponding symmetrical disulfides. The oxidation reactions were carried out under solvent-free reaction conditions within 15 min under the influence of microwave irradiation, as well as (for comparison) supported by conventional heating, to afford yields of the thiosulfonate <i>S</i>-esters in the range of 60–83%. The oxidation reaction appears to proceed (at least partly) via an intermediate symmetrical <i>vic</i>-disulfoxide.</p></div>