Facile Synthesis of 2-(4-Hydroxybiphenyl-3-yl)-1<i>H</i>-indoles from Anilines and 5′-Bromo-2′-hydroxyacetophenone

<div><p></p><p>2-Arylindoles are attractive scaffolds because they are found in many pharmacologically active molecules. In this study, we describe the facile synthesis of diverse 2-(2-hydroxyphenyl)-1<i>H</i>-indoles from anilines and 5′-bromo-2′-hydroxyacetophenone in two steps using palladium-catalyzed indole cyclization as a key reaction. The indole cyclization was primarily controlled by the substituent properties of anilines. Suzuki-coupling reactions of 2-(5′-bromo-2′-hydroxyphenyl)-1<i>H</i>-indoles with arylboronic acids provided the corresponding 2-(4-hydroxybiphenyl-3-yl)-1<i>H</i>-indoles in moderate yield.</p></div>