Facile Lewis Acid Catalyzed Synthesis of <i>C</i><sub>4</sub> Symmetric Resorcinarenes

The Lewis acid catalyzed condensation of 3-methoxyphenol with octanal produced the <i>C</i><sub>4</sub> symmetric calix[4]resorcinarene <b>2</b>, in high yield. Of the numerous stereo- and regioisomers possible, the rccc isomer with <i>C</i><sub>4</sub> symmetry was the only product isolated (as a racemate). The structure has been established by single-crystal X-ray structure analysis.