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Exposure of Lung Epithelial Cells to Photochemically Aged Secondary Organic Aerosol Shows Increased Toxic Effects
journal contribution
posted on 2018-06-11, 00:00 authored by Pratiti
Home Chowdhury, Quanfu He, Tatyana Lasitza Male, William H. Brune, Yinon Rudich, Michal PardoAdverse
health effects due to exposure to particulate matter (PM)
are among the most important global environmental health risks. However,
the effects of exposure to secondary organic aerosols (SOA), a major
component of the global aerosol, are largely unknown. Here we exposed
lung epithelial cells (A549) to fresh and aged SOA particles and investigated
the effect of SOA atmospheric aging on cell viability and gene expression.
Naphthalene- and α-pinene-derived SOA were formed in an oxidation
flow reactor that simulates atmospheric SOA formation and aging dominated
by OH radical oxidation under NOx-free
conditions. The SOA mass and chemical composition were characterized
on-line using a scanning mobility particle sizer and aerosol mass
spectrometer. Fresh and aged SOA were directed to an air–liquid
interface cell exposure system. Aged naphthalene- and α-pinene-derived
SOA were somewhat more toxic than fresh SOA. Aged naphthalene SOA
contained peroxide levels that were higher than those of fresh SOA.
The level of induction of Nrf2 signaling increased following exposure
to aged naphthalene SOA. Given the global prevalence of SOA and its
observed toxicity, this study calls for more studies aimed at understanding
the underlying mechanics.
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Aged naphthalene SOAchemical compositionα- pinene-derived SOAPhotochemically AgedToxic EffectsSOA particlesAged naphthalenegene expressionlung epithelial cellsPMOHLung Epithelial CellsOrganic Aerosol Showsperoxide levelsscanning mobility particle sizerhealth risksSOA formationcell viabilitynaphthalene SOASOA massaerosol mass spectrometerNrf 2health effectsoxidation flow reactor
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