Expedient Five-Step Synthesis of SIB-1508Y from Natural Nicotine

2006-10-27T00:00:00Z (GMT) by Florence F. Wagner Daniel L. Comins
Altinicline (SIB-1508Y), an anti-Parkinson's agent, was prepared in five steps from natural nicotine in 32% overall yield via a regioselective substitution of the pyridine ring of (<i>S</i>)-nicotine.