Expedient Five-Step Synthesis of SIB-1508Y from
Natural Nicotine

Wagner, Florence F.; Comins, Daniel L.

doi:10.1021/jo0616052.s001

jo0616052_si_001.pdf (1.41 MB)

Expedient Five-Step Synthesis of SIB-1508Y from Natural Nicotine

journal contribution

posted on 2006-10-27, 00:00 authored by Florence F. Wagner, Daniel L. Comins

Altinicline (SIB-1508Y), an anti-Parkinson's agent, was prepared in five steps from natural nicotine in 32% overall yield via a regioselective substitution of the pyridine ring of (S)-nicotine.

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Keywords

nicotine agent SIB Natural NicotineAltinicline Synthesi Expedient regioselective substitution pyridine ring

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