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Exon expression pattern of concussion predicts clinical diagnosis.

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posted on 2017-09-01, 17:29 authored by Jimmaline J. Hardy, Scott. R. Mooney, Andrea. N. Pearson, Dawn McGuire, Daniel. J. Correa, Roger P. Simon, Robert Meller

A. Hierarchical clustering shows pattern of separation between concussed and controls based on expression of 29 exons (x-axis) B. Principle component analysis plot shows the exon expression patterns separate due to concussion status. C Results of testing SVM generated model of 25 exons (Table 2) on testing data set, using a diagnosis of PCS/ concussion as the positive call. Note the accuracy was 86%, sensitivity 80% and specificity of 89%.

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