Ex Post Glycoconjugation of Phthalocyanines

For the first time, fully fledged phthalocyanines (Pc<i>s</i>) were ex post glycoconjugated, that is, via 1,3-dipolar cycloaddition reaction. This divergent approach gains rapid access to a broad range of highly diverse Pc<i>s</i> bearing chemically sensitive substituents. This will be a breakthrough in generating structure−activity relationships (SAR) for the development of novel bioactive molecules.