Evolutionary scenario proposed for the origin and evolution of the extended Hox and ParaHox gene clusters

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Taken from "Genesis and evolution of the and genes and the extended Hox and ParaHox gene clusters"

Genome Biology 2003;4(2):R12-R12.

Published online 23 Jan 2003

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC151302.

Copyright © 2003 Minguillón and Garcia-Fernàndez; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL

It implies an ancestor gene initially linked to the gene (step 1) that gives rise after duplication to and genes, which is paralleled by the generation of primordial Hox and ParaHox clusters, forming a continuous array containing all the Hox-like genes (the 'coupled' Hox-like cluster; step 3). See text for details.