Fig 5.tif (520.03 kB)
Evaluation of baseline pathway gene expression between sensitive and resistant CRC cell lines.
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posted on 2017-11-01, 17:38 authored by Aaron J. Scott, Eun-Kee Song, Stacey Bagby, Alicia Purkey, Martin McCarter, Csaba Gajdos, Kevin S. Quackenbush, Benjamin Cross, Todd M. Pitts, Aik Choon Tan, S. Gail Eckhardt, Hubert Fenton, John Arcaroli, Wells A. MessersmithA) Pathway analysis of sensitive and resistant gene expression and KEGG pathway diagram shows that adherens junction is a pathway enriched in sensitive CRC cell lines (red shows the genes that are increased in the sensitive cell lines and include Src and FAK. B) Src and C) FAK gene expression are significantly elevated in sensitive when compared to resistant CRC cell lines.
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Src pathwayanti-proliferative activity72 hours17 CRC explantsSrc expressiondasatinib treatmentCRC explantsG 1 inhibitionbaseline increaseanti-tumor effectsMethods CRC cell lines50 CRC cell linestumor growth inhibitionanti-invasive activityvivo efficacyG 1 cell cycle arrestsulforhodamine Bexplant mouse model Background DysregulationFAK gene expression17 patient-derived CRC explantsSRBxenograft mouse modelanti-tumor activityPDXpatient-derived tumor explantConclusion DasatinibCRC cell linesTGIcolorectal cancer cell linesIC28 days
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