gpom_a_1323216_sm5425.docx (1.41 MB)
Evaluation of macrophage injury and activation by amphotericin B-loaded polymeric nanoparticles
Version 2 2017-08-11, 14:20
Version 1 2017-06-09, 13:19
journal contribution
posted on 2017-08-11, 14:20 authored by MD. Ashraf, Javed Abrar Farooqi, Kalim JavedThe objectives of present work were to prepare water soluble nanoformulation of amphotericin B by radical polymerization using N-isopropylacrylamide–acrylic acid and vinyl pyrrolidone for targeted delivery and minimized toxicity in mild experimental conditions with relatively narrow size distribution. The prepared formulations were extensively characterized in terms of size, morphology, thermal stability, drug loading and toxicity. The results demonstrates that the prepared nanoformulation have the potential to deliver amphotericin B with increased bioavailability and cellular uptake.
History
Usage metrics
Categories
Keywords
Amphotericin Bdrug deliverymacrophageNIPAMphagocytosisNIPAM: N-isopropylacrylamideAA: acrylic acidVP: vinyl pyrrolidoneAmB: amphotericin BMBA: N,N-methylene-bis-acrylamideROS: reactive oxygen speciesSOD: superoxide dismutaseDSC: differential scanning calorimeterTGA: thermogravimetric analysisDNA: deoxy ribonucleic acidIFN-γ, type II interferonTGF: transforming growth factor
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC