ol6b01093_si_001.pdf (1009.27 kB)
Euphorikanin A, a Diterpenoid Lactone with a Fused 5/6/7/3 Ring System from Euphorbia kansui
journal contribution
posted on 2016-05-26, 20:13 authored by Dong-Qing Fei, Le-Le Dong, Feng-Ming Qi, Gai-Xia Fan, Hui-Hong Li, Zheng-Yu Li, Zhan-Xin ZhangEuphorikanin A (1), an unprecedented diterpenoid lactone
which possesses a novel 5/6/7/3-fused tetracyclic ring skeleton, was
isolated from the roots of Euphorbia kansui. The
chemical structure and absolute stereochemistry were elucidated on
the basis of extensive spectroscopic methods and single-crystal X-ray
diffraction analysis. Compound 1 exhibited moderate cytotoxicity
against two human tumor cell lines HeLa and NCI-446. A proposed biosynthetic
pathway of compound 1 is also described.