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Estimation of Physiological Conjugate Stability In Vitro.

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posted on 2016-06-23, 07:05 authored by Steve Knutson, Erum Raja, Ryan Bomgarden, Marie Nlend, Aoshuang Chen, Ramaswamy Kalyanasundaram, Surbhi Desai

The fluorescent ADC and hydrolyzed controls were incubated in PBS at 37°C, and liberated paclitaxel was extracted and quantified. Degree of hydrolysis was defined as the ratio of extracted paclitaxel from test samples compared to hydrolyzed controls. Data points represent triplicate extracted samples (n = 3). Error bars denote standard error.

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