Erratum: Significant Associations between <i>CCL5 </i>Gene Polymorphisms and Post-Transplantational Diabetes Mellitus in Korean Renal Allograft Recipients
2017-07-25T13:37:05Z (GMT) by
<i>Background:</i> Post-transplantational diabetes mellitus (PTDM) is a serious metabolic complication that may follow renal transplantation. The expression of chemokine (C-C motif) ligand 5 (CCL5) is inversely related to pancreatic β-cell function; thus, specific <i>CCL5</i> gene polymorphisms are considered to be risk factors for diabetes. In this study, we investigated the association between <i>CCL5</i> gene polymorphisms and the occurrence of PTDM in Korean patients who had undergone renal transplants. <i>Methods:</i> A total of 311 patients who had received kidney transplants without a prior history of diabetes were included. Three single nucleotide polymorphisms (SNPs) of the <i>CCL5 </i>gene were genotyped from genomic DNA with direct sequencing. <i>Results:</i> PTDM developed in 56 patients (18.0%). The results showed that the allele frequencies of <i>CCL5</i> gene polymorphisms, rs2107538*T, rs2280789*C and rs3817655*A were significantly higher in the patients with PTDM than in those without PTDM. In multiple logistic regression analysis, 3 SNPs (rs2107538, rs2280789 and rs3817655) of the <i>CCL5</i> gene were significantly associated with the development of PTDM in the codominant 2 and recessive models. Among haplotypes of the 3 polymorphisms, the frequency of the TCA haplotype was significantly higher in patients with PTDM than in those without PTDM. <i>Conclusions:</i> Our results indicated that genetic polymorphisms of the <i>CCL5</i> gene were associated with PTDM, suggesting that the <i>CCL5</i> gene might confer susceptibility to PTDM in patients who receive renal transplants.