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Enhanced Bioconcentration of Bisphenol A in the Presence of Nano-TiO2 Can Lead to Adverse Reproductive Outcomes in Zebrafish
journal contribution
posted on 2016-01-19, 00:00 authored by Qi Fang, Qipeng Shi, Yongyong Guo, Jianghuan Hua, Xianfeng Wang, Bingsheng ZhouTitanium
dioxide nanoparticles (n-TiO2) and bisphenol
A (BPA) are widespread environmental contaminants in the aquatic environment.
We hypothesized that n-TiO2 may adsorb BPA, and thus modify
its bioavailability and toxicity to aquatic organisms. In this study,
the bioavailability and toxicity of BPA (0, 2, 20, 200 μg/L)
was investigated in the presence of n-TiO2 (100 μg/L).
The n-TiO2 sorbed BPA and the resulting nanoparticles were
taken up by zebrafish, where they translocated to the liver, brain,
and gonad tissues. Increased tissue burdens of both BPA and n-TiO2 were observed following coexposure, and they also caused
a reduction in plasma concentrations of estradiol (E2),
testosterone (T), follicle-stimulating hormone (FSH), and luteinizing
hormone (LH). Plasma vitellogenin (VTG) concentrations were significantly
increased in males and females upon exposure to BPA. Histological
examination of the ovary and testes did not show obvious morphological
alterations; however, inhibition of egg production was noted in the
presence of n-TiO2. The results indicated that n-TiO2 acts as a carrier of BPA and enhances its bioconcentration
in zebrafish, leading to endocrine disruption and impairment of reproduction.