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Enantioselective total syntheses of (−)-clavaminol A and deacetyl (+)-clavaminol H

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posted on 2018-08-10, 13:34 authored by Rachana Pandey, Anju Gehlawat, Ranjana Prakash, Satyendra Kumar Pandey

An efficient enantioselective approach to the syntheses of (−)-clavaminol A and deacetyl (+)-clavaminol H is presented, starting from n-decanol. The synthesis features Sharpless asymmetric dihydroxylation (AD), regioselective epoxide formation/opening and α-tosylation as key steps.

Funding

The authors (R.P. and S.K.P.) acknowledge the research grant No. 02(0309)/17/EMR-II facilitated by the CSIR (Council for Scientific and Industrial Research), New Delhi, India for the carrying out the study.

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    Synthetic Communications

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    Keywords

    2-amino-3-alkanolsclavaminolscytotoxicSharpless ADregioselective

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    CC BY 4.0

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