Enantioselective total syntheses of (−)-clavaminol A and deacetyl (+)-clavaminol H

<p>An efficient enantioselective approach to the syntheses of (−)-clavaminol A and deacetyl (+)-clavaminol H is presented, starting from <i>n</i>-decanol. The synthesis features Sharpless asymmetric dihydroxylation (AD), regioselective epoxide formation/opening and <i>α</i>-tosylation as key steps.</p>