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Enantioselective Synthesis of Functionalized Fluorinated Cyclohexenones via Robinson Annulation Catalyzed by Primary−Secondary Diamines

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posted on 2010-01-01, 00:00 authored by Hai-Feng Cui, Ying-Quan Yang, Zhuo Chai, Peng Li, Chang-Wu Zheng, Shi-Zheng Zhu, Gang Zhao
Primary−secondary diamine catalysts were used to catalyze the asymmetric Robinson annulation to synthesize multiply substituted fluorinated chiral cyclohexenones with two contiguous stereogenic centers, one of which is a fluorinated quaternary chiral center, with excellent enantioselectivities and diastereoselectivities in moderate to good yields.

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