ol7b03332_si_001.pdf (67.73 MB)
Enantioselective Synthesis of α‑Acetal-β′-Amino Ketone Derivatives by Rhodium-Catalyzed Asymmetric Hydrogenation
journal contribution
posted on 2017-11-18, 17:30 authored by Quentin Llopis, Gérard Guillamot, Phannarath Phansavath, Virginie Ratovelomanana-VidalA range of β-keto-γ-acetal
enamides has been synthesized and transformed into the corresponding
enantioenriched α-acetal-β′-amino ketones with
enantioinductions of up to 99% by using rhodium/QuinoxP*-catalyzed
enantioselective hydrogenation under mild conditions. This method
also proved to be highly chemoselective toward the reduction of the
C–C double bond.