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Enantioselective Synthesis of α‑Acetal-β′-Amino Ketone Derivatives by Rhodium-Catalyzed Asymmetric Hydrogenation

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journal contribution
posted on 2017-11-18, 17:30 authored by Quentin Llopis, Gérard Guillamot, Phannarath Phansavath, Virginie Ratovelomanana-Vidal
A range of β-keto-γ-acetal enamides has been synthesized and transformed into the corresponding enantioenriched α-acetal-β′-amino ketones with enantioinductions of up to 99% by using rhodium/QuinoxP*-catalyzed enantioselective hydrogenation under mild conditions. This method also proved to be highly chemoselective toward the reduction of the C–C double bond.

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