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Enantioselective Activation of Stable Carboxylate Esters as Enolate Equivalents via N-Heterocyclic Carbene Catalysts

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posted on 2012-04-20, 00:00 authored by Lin Hao, Yu Du, Hui Lv, Xingkuan Chen, Huishen Jiang, Yaling Shao, Yonggui Robin Chi
The first N-Heterocyclic Carbene (NHC) mediated activation of stable carboxylate esters to generate enolate intermediates is disclosed. The catalytically generated arylacetic ester enolates undergo enantioselective reactions with α,β-unsaturated imines.

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    Organic Letters

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    Keywords

    enantioselective reactionsEnantioselective ActivationNHCEnolate Equivalentsiminearylacetic ester enolatesStable Carboxylate EstersCarbeneCatalystsTheactivationcarboxylate esterscatalyticallyenolate intermediates

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