L93 20181117 PhD Final signed Amended_Redacted.pdf (48.59 MB)
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Emergence and Margins in Head and Neck Cancer: A new understanding

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thesis
posted on 13.03.2019 by ELIZABETH ANNE SIGSTON
Cancer has been widely accepted as a genetic disease. This thesis challenges this assumption and proposes that cancer be considered as an emergent complex system. A new framework for carcinogenesis and cancer progression is presented. This framework is applied to identify biological markers with the potential to predict recurrence in oral cancer. A simple dual staining technique is developed to test the identified biomarkers. The results support the use of these biomarkers as a predictor of recurrence over and above traditionally measured cancer clearance.

History

Principal supervisor

Bryan Williams

Additional supervisor 1

Julian Smith

Year of Award

2018

Department, School or Centre

Molecular and Translational Sciences

Additional Institution or Organisation

Monash Health

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences

Exports