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Efficient synthesis of novel Naphthacene derivatives based on Thiouracil

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journal contribution
posted on 2018-06-18, 18:32 authored by Fahimeh Sadat Hosseini, Mohammad Bayat

A simple one-pot three-component synthesis of fused thiouracils from readily available starting materials including 2-hydroxy-1,4-naphthoquinone, aromatic aldehydes and 6-amino-2-thiouracil in good yields is described. The sequences of cascade reactions include Knoevenagel condensation, Michael addition and cyclocondensation.

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