Efficient method for the synthesis of 1,2,3-triazole functionalized isoxazolidine derivatives by 1,3-dipolar cycloaddition of nitrones with terminal olefins

<p>1-Phenyl-1,2,3-triazole-4-carbaldehyde <b>1</b> was treated with different <i>N</i>-alkyl hydroxylamine hydrochlorides <b>2</b> using NaHCO<sub>3</sub> to obtain 1,2,3-triazole substituted <i>N</i>-alkyl nitrones <b>3a–c</b>. The nitrones <b>3a–c</b> were further reacted with different substituted olefins and furnished 2-alkyl-3-(1-phenyl-1<i>H</i>-1,2,3-triazol-4-yl)-5-(substituted)isoxazolidine derivatives <b>4a–p</b> in high yields via 1,3-dipolar cycloaddition reaction.</p>