lsyc_a_1533974_sm0340.doc (2.03 MB)
Efficient and selective microwave-assisted copper-catalyzed synthesis of quinazolinone derivatives in aqueous
journal contribution
posted on 2018-11-16, 10:33 authored by Fang Ke, Caiqin Liu, Peng Zhang, Jianhua Xu, Xiaole ChenMicrowave-assisted copper-catalyzed cascade reactions between 2-halobenzoic acids and amidines to synthesize quinazolinone derivatives in water are reported. A variety of target products were obtained in good to excellent yields up to 94%. Its application was performed by the synthesis of 4-(1H-benzo[d]imidazol-2-ylthio)-6-methoxypteridine, which displayed significant anti-proliferation effect.