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Efficient Synthesis of Substances Related to Cinacalcet Hydrochloride via Heck Coupling

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Version 4 2014-10-02, 00:02
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journal contribution
posted on 2014-10-02, 00:00 authored by Fan Lei, Boyi Qu, Xiaolong Li, Li Guo, Mei Guan, Li Hai, Hui Jin, Yong Wu

Efficient synthetic methods to process substances related to cinacalcet hydrochloride 1, generated during the preparation, were described. The compounds were identified as [1-(7,8-dihydro-naphthalen-1-yl)-ethyl]-[3-(3-trifluoromethyl-phenyl)-propyl]-amine hydrochloride 2,[1-(5,6,7,8-tetrahydro-naphthalen-1-yl)-ethyl]-[3-(3-trifluoromethyl-phenyl)-propyl]-amine hydrochloride 3 and [1-(naphthalen-2-yl)-ethyl]-[3-(3-trifluoromethyl-phenyl)-propyl]-amine hydrochloride 4. All were prepared from commercially available materials in several linear steps and characterized by their respective spectral data.

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