Efficient Synthesis of Substances Related to Cinacalcet Hydrochloride via Heck Coupling

<div><p></p><p>Efficient synthetic methods to process substances related to cinacalcet hydrochloride <b>1</b>, generated during the preparation, were described. The compounds were identified as [1-(7,8-dihydro-naphthalen-1-yl)-ethyl]-[3-(3-trifluoromethyl-phenyl)-propyl]-amine hydrochloride <b>2</b>,[1-(5,6,7,8-tetrahydro-naphthalen-1-yl)-ethyl]-[3-(3-trifluoromethyl-phenyl)-propyl]-amine hydrochloride <b>3</b> and [1-(naphthalen-2-yl)-ethyl]-[3-(3-trifluoromethyl-phenyl)-propyl]-amine hydrochloride <b>4</b>. All were prepared from commercially available materials in several linear steps and characterized by their respective spectral data.</p> </div>