co7b00002_si_001.pdf (3.77 MB)
Efficient Synthesis of Fused Oxazepino-isoquinoline Scaffolds via an Ugi, Followed by an Intramolecular Cyclization
journal contribution
posted on 2017-03-08, 00:00 authored by Yong Li, Jiang-Ping Meng, Jie Lei, Zhong-Zhu Chen, Dian-Yong Tang, Jin Zhu, Jin Zhang, Zhi-Gang XuA mild
and efficient protocol was developed for the synthesis of
oxazepino-isoquinolines via a one-pot Ugi four-component reaction,
followed by the intramolecular addition of the resulting alcohol to
an alkyne moiety under microwave irradiation conditions. Notably,
this process only required one purification step, providing facile
access to two series of complex and potentially interesting biologically
active scaffolds.