Efficient Post-Macrocyclization Functionalizations of Oxacalixarenepyrimidines
2008-02-21T00:00:00Z (GMT) by
Diversely functionalized oxacalixarenepyrimidines have been synthesized starting from a bis(methylsulfanyl)-substituted oxacalixarene by two efficient post-macrocyclization pathways. Functionalized aryl groups were introduced on the pyrimidine building block via Liebeskind−Srogl cross-coupling reactions, while a variety of O-, S-, N-, and C-nucleophiles were inserted on the calixarene skeleton by nucleophilic aromatic substitution reactions on the bis(methylsulfonyl)oxacalixarene analogue.
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