Effects of transient OGD on mEPSCs in CA1 neurons (n = 8).

Experiments were performed in the presence of TTX (1.0 μM). (A) Voltage clamp recording from a CA1 pyramidal cell before, during transient ischemia, and 10 minutes after recovery. Note the transit inward currents, which represented mEPSCs, increase in frequency. (B) Frequency of mEPSCs increased during transient OGD. (C) Cumulative curve plot showing reduced intervals (increased frequencies) of the mEPSCs during OGD compared to control and recovery. (D) Amplitude of mEPSCs did not change in transient ischemia. (E) The decay time of mEPSC was not altered by the 2 min OGD.